Brian T. Chait

(1949)
The Rockefeller University

Notable Achievements:

• ESI to probe non-covalent complexes
• ESI to probe solution conformation of proteins
• H/D exchange with ESI-MS for protein analysis
• Proteolysis with mass spectrometry for probing protein solution structure
• Stable isotope quantitation of protein expression and site-specific phosphorylation
• ESI mass spectrometer using a heated capillary as an ion transfer device
• Mapping interaction of DNA on DNA-binding proteins
• Database searching algorithms for protein identification
• Developed the utility of affinity mass spectrometry
• Protein ladder sequencing

Biographical Sketch

• Born July 6, 1949
• Received B.Sc. (Natural Sciences) from the University of Cape Town, South Africa, 1969
• Received B.Sc. Hons. (Physics) from the University of Cape Town, South Africa, 1970
• Received Ph.D. (Nuclear Physics) from the University of Oxford, United Kingdom, 1976

Academic Appointments

• Camille and Henry Dreyfus Professor, The Rockefeller University, New York, N.Y., 1995 - Present
• Professor, The Rockefeller University, New York, N.Y., 1991 - Present
• Director, The Rockefeller University Mass Spectrometric Biotechnology Research Resource, New York, N.Y., 1988 - Present
• Associate Professor, The Rockefeller University, New York, N.Y., 1985 - 1991
• Associate Director, The Rockefeller University Mass Spectrometric Biotechnology Research Resource The Rockefeller University, New York, N.Y., 1983 - 1988
• Assistant Professor, The Rockefeller University, New York, N.Y., 1981 - 1985
• Research Associate, The Rockefeller University, New York, N.Y., 1979 - 1981
• Postdoctoral Associate, Physics Department, University of Manitoba, Canada, 1977 - 1979
• Graduate Research for Doctor of Philosophy Degree at the Univ. of Oxford, Nuclear Physics Laboratory, U.K., 1972 - 1976

Awards and Honors

• Co-recipient of AAAS Newcombe Cleveland Prize, 1998
• Columbia University IAP Lecturer, 1999
• Bijvoet Medal, 2000
• Fellow New York Academy of Sciences, 2001
• ACS Field & Franklin Award for Oustanding Achievement in Mass Spectrometry, 2002

US Patents

Publications