1962 - Mass Spectrometry Imaging

Imaging by mass spectrometry was initially developed at the University of Orsay by Georges Slodzian and Raymond Castaing and was applied to the microanalysis of mineral samples. This "ion microscopy" was first utilized in Biology by Pierre Galle in 1970 (Galle 1970) yet more recently different ion sources have been applied to biological imaging such as SIMS with buckyball, MALDI, DESI and DART.

• Castaing R., Slodzian G.
  Microanalyse par émission ionique secondaire (Microanalysis by secondary ion emission)
  Journal De Microscopie, 1962, 1(), p.395

  
  
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• Galle P.
  Sur une nouvelle methode d'analyse cellulaire utilisant le phenomene d' << emission ionique secondaire >>
  Ann. Phys. Biol. Med., 1970, 42(), p.83

  
  
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• Colliver T.L., Brummel C.L., Pacholski M.L., Swanek F.D., Ewing A.G., Winograd N.
  Atomic and Molecular Imaging at the Single-Cell Level with TOF-SIMS
  Anal. Chem., 1997, 69(13), p.2225

  
  
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• Stoeckli M., Chaurand P., Hallahan D.E., Caprioli R.M.
  Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues
  Nat Med., 2001, 7(4), p.493

  
  
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• Ostrowski S.G., Van Bell C.T., Winograd N., Ewing A.G.
  Mass Spectrometric Imaging of Highly Curved Membranes During Tetrahymena Mating
  Science, 2004, 305(), p.71

  
  
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• Cody R.B., Laramee J.A., Durst H.D.
  Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions
  Anal. Chem., 2005, 77(8), p.2297

  
  
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• Cooks R.G., Ouyang Z., Takats Z., Wiseman J.M.
  Ambient Mass Spectrometry
  Science, 2006, 311(5767), p.1566

  
  
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