1947 - Preparative Mass Spectrometry

In the early 1940s a mass spectrometry-based separation approach to enrich radioactive uranium 235U from the natural isotopic distribution of uranium. This method used Calutron mass spectrometers to separate ions according to their mass-to-charge ratio (m/z), and once separated, the ions were collected. This preparative mass spectrometry approach was used to purify radioactive 235U, which was then used to construct the first nuclear weapon. It was recently demonstrated that viruses as well as other types of molecules could also be separated and collected using electrospray ionization mass spectrometry.

• Siuzdak G., Bothner B., Yeager M., Brugidou C., Fauquet C.M., Hoey K., Chang C.M.
  Mass Spectrometry and Viral Analysis
  Chemistry & Biology, 1996, 3(), p.45

  
  
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• Siuzdak G., Hollenbeck T., Bothner B.
  Preparative Mass Spectrometry with Electrospray Ionization
  Journal of Mass Spectrometry, 1999, 34(), p.1087

  
  
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• Ouyang Z., Takats Z., Blake T.A., Gologan B., Guymon A.J., Wiseman J.M., Oliver J.C., Davisson V.J., Cooks R.G.
  Preparing protein microarrays by soft-landing of mass-selected ions
  Science, 2003, 301(5638), p.1351

  
  
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• Parkins W.E.
  The Uranium Bomb, the Calutron, and the Space-Charge Problem
  Physics Today, 2005, 45(), p.

  
  
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