and Mass Spectrometry

Research and Publications

The Center is engaged in developing and applying mass spectrometry-based technologies in metabolomics. Our cloud-based data processing and analysis technologies (XCMS and METLIN) are constantly changing and adapting to the new challenges in this exciting field. Currently they facilitate the research of thousands of scientists worldwide. Our nanostructure imaging mass spectrometry (NIMS) technology is a matrix-free solution to tissue imaging, activity screening and analyzing nano-arrays. NIMS is also continuously evolving to meet the demands in metabolic mass spectrometry imaging.

203 Johnson C., Dejea C., Edler D., Hoang L., Santidrian A., Felding B., Ivanisevic J., Cho K., Wick E., Hechenbleikner E., Uritboonthai W., Goetz L., Casero R., Pardoll D., White J., Patti G., Sears C., and Siuzdak G.
Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
Cell Metabolism, in press, 2015                      
202 Kurczy M., Zhu Z., Ivanisevic J., Schuyler A., Lalwani K., Santidrian A., David J., Giddabasappa A., Olivos H., O'Brien P., Franco L., Fields M., Paris L., Friedlander M, Johnson C., Epstein A., Gendelman H., Felding B., Patti G., Spilker M., Siuzdak G.
Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids
Nature Communications, in press, 2015                 PMID: 25601659     
201 Johnson C., Ivansevic J., Benton P., Siuzdak G.
Bioinformatics: The Next Frontier of Metabolomics
Analytical Chemistry, 2015 87(1) 147-156      PDF File           PMID: 25389922     PMCID: 4287838
200 Kurczy M., Northen T., Trauger, S.A., Siuzdak, G.
Nanostructure Imaging Mass Spectrometry: The Role of Fluorocarbons in Metabolite Analysis and the Road to Yoctomole Level Sensitivity
"Methods in Molecular Biology: Mass Spectrometry Imaging of Small Molecules", 2015 1203 141-9      PDF File           PMID: 25361674     
199 Benton H.P., Ivanisevic J., Mahieu N., Kurczy M., Johnson C., Franco L., Rinehart D., Valentine E., Gowda H., Ubhi K., Tautenhahn R., Gieschen A., Fields M.,Patti G., Siuzdak G.
Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling
Analytical Chemistry, 2015 87(2) 884-891      PDF File           PMID: 25496351     PMCID: 4303330
198 Ivanisevic J., Epstein A., Kurzcy M., Benton H.P., Uritboonthai W., Fox H.S., Boska M.D., Gendelman H.E., Siuzdak G.
Brain Region Mapping using Global Metabolomics
Chemistry & Biology, (cover and feature article), 2014 21(11) 1575-1584.      PDF File           PMID: 25457182     PMCID: 4304924
197 Benton H.P., Ivanisevic J., Rinehart D., Epstein A.A., Gendelman H., Siuzdak G.
An Interactive Heat Map for Metabolomic Data Visualization
in press, 2014      PDF File                
196 Ivanisevic J., Elias D., Deguchi H., Averell P.M., Zhu Z., Tautenhahn R., Johnson C.H., Griffin J., Patti G.J., Siuzdak G.
Arterial and Venous Plasma Metabolomics: Reflecting Intra-Tissue Metabolic Activity
, 2014                      
195 Rinehart D., Johnson C.H., Nguyen T., Ivanisevic J., Benton H.P., Lloyd J., Deutschbauer A., Arkin A., Patti G.J., Siuzdak G.
Metabolomic Data Streaming for Biology-Dependent Data Acquisition
Nature Biotechnology, 2014 32(6) 524-527      PDF File           PMID: 24911492     PMCID: 4112958
194 Patti G.J., Tautenhahn R., Johannsen D., Kalisiak E., Ravussin E., Bruning J.C., Dillin A., Siuzdak G.
Meta-Analysis of Global Metabolomic Data Identifies Metabolites Associated with Life-Span Extension
Metabolomics, 2014 vol10(4) 737-743      PDF File           PMID 25530742     PMCID: 4267291
193 Kiyota T., Morrison C.M., Kurczy M.E., Zhang G., Epstein A.A., Boska M.D., Siuzdak G., Gendelman H.E.
Presenilin-1 familial Alzheimer´s disease mutation affects hippocampal neurogenesis in CCL2 null mice independent of ß-amyloidosis
submitted, 2014                      
192 Cho K., Mahieu N., Ivanisevic J., Uritboonthai W., Chen Y-Jr., Siuzdak G., Patti G.
isoMETLIN: A Database for Isotope-Based Metabolomics
Analytical Chemistry, 2014 86(19) 9358-61      PDF File           PMID: 25166490      
191 Gowda H., Ivanisevic J., Johnson C.H., Kurczy M.E., Benton H.P., Rinehart D., Nguyen T., Ray J., Kuehl J., Arevalo B., Westenskow P.D., Wang J., Arkin A.P., Deutshbauer A.M., Patti G.J., Siuzdak G.
Interactive XCMS Online: Simplifying Advanced Metabolomic Data Processing and Subsequent Statistical Analyses
Analytical Chemistry, 2014 86(14) 6931-9      PDF File           PMID: 24934772     PMC4215863
190 Johnson C.H., Fisher T.S., Hoang L.T., Felding B.H., Siuzdak G., O'Brien P.J.
Luciferase does not Alter Metabolism in Cancer Cells
Metabolomics (cover article), 2014      PDF File           PMID: 24791164     PMC4002053
189 Deguchi H., Elias D.J., Trauger S., Zhang H.M., Kalisiak E., Siuzdak G., Griffin J.H.
Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids.
Br J Haematol., 2014                 PMID: 24450944     PMC3984601
188 Ivanisevic J., Zhu Z., Plate L., Tautenhahn R., Chen S., O’Brien P.J., Johnson C.H., Marletta M.A., Patti G.J., Siuzdak G.
Toward 'Omic' Scale Metabolite Profiling: A Dual Separation – Mass Spectrometry Approach for Coverage of Lipids and Central Carbon Metabolism
Analytical Chemistry, 2013 85(14) 6876-84      PDF File           PMID: 23781873     PMC3761963
187 Zhu Z-J., Schultz A.W., Wang J., Johnson C.H., Yannone S.M., Patti G.J., Siuzdak G.
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database
Nature Protocols, 2013 8 451-460      PDF File           PMID: 23391889     PMC3666335
186 Patti G.J., Tautenhahn R., Rinehart D., Cho K., Nikolskiy I., Johnson C., Siuzdak G.
A View from Above: The Cloud Plot for Visualizing Global Metabolomic Data
Analytical Chemistry (selected as an Editor's Highlight), 2013 85(2) 798-804      PDF FIle           PMID: 23206250     PMC3716252
185 O'Brien P.J., Lee M., Spilker M.E., Zhang C., Yan Z., Nicholls T.C., Li W., Johnson C.H., Patti G.J., Siuzdak G.
Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging
Cancer and Metabolism, 2013 1(1) 4      PDF FIle           PMID: 24280026     PMC3834492
184 Patti G.J., Siuzdak G.
Mass Spectrometry in Biochemistry
book in preparation, 2013                      
183 Blankman J.L., Long J.Z., Trauger S.A., Siuzdak G., Cravatt B.
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
Proc Natl Acad Sci USA, 2013 110(4) 1500-5      PDF Link           PMID: 23297193     PMC3557017
182 Ukrohne T.U., Westenskow P.D., Kurihara T., Friedlander D.F., Lehmann M., Dorsey A.L., Li W.L., Zhu S.Y., Schultz A., Wang J.H., Siuzdak G., Ding S., Friedlander M.
Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells
Stem Cells Translational Medicine, 2012 1(2) 96-109      PDF File           PMID: 22532929     PMC3328503
181 Tautenhahn R., Cho K. Y., Uritboonthai W., Zhu Z., Patti G. J., Siuzdak G.
An accelerated workflow for untargeted metabolomics using the METLIN database
Nature Biotechnology, 2012 30(9) 826-8      PDF File      DOI: 10.1038/nbt.2348     PMID: 22965049     PMC3666346
180 Tautenhahn R., Patti G.J., Rinehart D., Siuzdak G.
XCMS Online ( A web-based platform to process untargeted metabolomic data
Analytical Chemistry, 2012 84(11) 5035-5039      PDF File      DOI: 10.1021/ac300698c     PMID: 22533540     PMC3703953
179 Patti G.J., Yanes O., Shriver L., Courade J-P., Tautenhahn R., Manchester M., Siuzdak G.
Metabolomics Implicates Altered Sphingolipid Metabolites in Chronic Pain of Neuropathic Origin
Nature Chemical Biology, 2012 8 232-234      PDF File      Supplemental File     PMID: 22267119     PMC3567618
178 Patti G.J., Yanes O., Siuzdak G.
Innovation: Metabolomics: the apogee of the omics trilogy.
Nat Rev Mol Cell Biol., 2012 13 263-269      PDF File           PMID22436749     PMC3682684
177 Patti G.J., Tautenhahn R., Siuzdak G.
Meta-Analysis of untargeted metabolomic data from multiple profiling experiments
Nature Protocols, 2012 7(3) 508-516      PDF File           PMID: 22343432     PMC3683249
176 Greving M., Cheng X., Reindl W., Bowen B., Deng K., Louie K., Nyman M., Cohen J., Singh A., Simmons B., Adams P., Siuzdak G., Northen T.
Acoustic deposition with NIMS as high throughput enzyme activity assay
Analytical and Biochemical Chemistry, 2012      PDF File           PMID: 22407334     
175 Panopoulos A.D., Yanes O., Ruiz S., Kida Y.S., Diep D., Tautenhahn R., Herreras A., Batchelder E.M., Plongthongkum N., Lutz M., Berggren W.T., Zhang K., Evans R.M., Siuzdak G., Izpisua-Belmonte J.C.
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming
Cell Research, 2012 22 168-177      PDF Link           PMID: 22064701     PMC3252494
174 Patti G.J, Tautenhahn R., Fonslow B.R., Cho Y., Deutschbauer A., Arkin A., Northen T., Siuzdak G.
Meta-Analysis of Global Metabolomics and Proteomics Data to Link Alterations with Phenotype
Spectroscopy (cover article), 2011 26(3) 151-154      PDF Link                
173 Tautenhahn R., Patti G.J., Kalisiak E., Miyamoto T., Schmidt M., Fan Y.L., McBee J., Baliga N.S., Siuzdak G.
metaXCMS: Second-Order Analysis of Untargeted Metabolomics Data
Analytical Chemistry, 2011 83 696-700      PDF Link           PMID: 21174458     PMC3654666
172 Yanes O., Tautenhahn R., Patti G., Siuzdak G.
Expanding Coverage of the Metabolome for Global Metabolite Profiling
Analytical Chemistry, 2011 83(6) 2152-2161      PDF Link           PMID: 21329365     PMC3285547
171 Greving M.P., Patti G.J., Siuzdak G.
Nanostructure-Initiator Mass Spectrometry (NIMS) Metabolite Analysis and Imaging
Analytical Chemistry, 2011 83(1) 2-7      PDF Link           PMID: 21049956     PMC3012143
170 Powers M.E., Smith P.A., Roberts T.C., Fowler B.J., King C.C., Trauger S.A., Siuzdak G., Romesberg F.E.
Type I Signal Peptidase and Protein Secretion in Staphylococcus epidermidis
Journal of Bacteriology, 2011 193(2) 340-348      PDF Link           PMID: 21075926     PMC3019839
169 Long J.Z., Cisar J.S., Miliken D., Niessen S., Wang C., Trauger S.A., Siuzdak G., Cravatt B.F.
Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids
Nature Chemical Biology, 2011 7 763-765                 PMID: 21926997     PMC3201731
168 Lancaster WA, Praissman JL, Poole FL II, Cvetkovic A, Menon AL, Scott JW, Jenney FE Jr, Thorgersen MP, Kalisiak E, Apon JA, Trauger SA, Siuzdak G, Tainer JA, Adams MWW
A Computational Framework for Proteome-Wide Pursuit and Prediction of Metalloproteins using ICP-MS and MS/MS Data
BMC Bioinformatics, 2011 12 1-12      PDF File           PMID: 21356119     PMC3058030
167 Marchetti V., Yanes O., Aguilar E., Wang M., Friedlander D., Moreno S., Storm K., Zhan M., Naccache S., Nemerow G., Siuzdak G., Friedlander M.
Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy
Scientific Reports, 2011 1(76) 1-12      PDF File           PMID: 22355595     PMC3216563
166 Pendyala G., Trauger S.A., Siuzdak G., Fox, H.S.
Short Communication: Quantitative Proteomic Plasma Profiling Reveals Activation of Host Defense to Oxidative Stress in Chronic SIV and Methamphetamine Comorbidity
Aids Research and Human Retrovirus, 2011 27(2) 179-182      PDF File           PMID: 20929344     PMC3045074
165 Patti G.J., Shriver L., Wassif C.A., Woo H-K., Uritboonthai W., Manchester M., Forbes D.P., Siuzdak G.
Nanostructure-Initiator Mass Spectrometry Imaging of Brain Cholesterol Metabolites in Smith-Lemli-Opitz Syndrome
Neuroscience, 2010 170(3) 858-64      PDF Link           PMID: 20670678     PMC2952448
164 Yanes O., Hsu J., Wong D.M., Sanchez-Ruiz A., Benton H.P., Trauger S.A., Despont C., Ding S., Siuzdak G.
Metabolic oxidation regulates embryonic stem cell differentiation
Nature Chemical Biology, 2010 6 411-417      PDF Link           PMID: 20436487     PMC2873061
163 Patti G.J., Woo H.K., Yanes O., Shriver L., Thomas D., Uritboonthai W., Apon J.V., Steenwyk R., Manchester M., Siuzdak G.
Detection of Carbohydrates and Steroids by Cation-Enhanced Nanostructure-Initiator Mass Spectrometry (NIMS) for Biofluid Analysis and Tissue Imaging
Analytical Chemistry, 2010 82(1) 121-128      PDF File           PMID: 19961200     PMC2802282
162 Kopp F., Komatsu T., Nomura D.K., Trauger S.A., Thomas J.R., Siuzdak G., Simon G.M., Cravatt B.K.
The Glycerophospho Metabolome and Its Influence on Amino Acid Homeostasis Revealed by Brain Metabolomics of GDE(-/-) Mice
Chemistry and Biology, 2010 17(8) 831-840      PDF Link           PMID: 20797612     PMC2931592
161 Facciotti M.T., Pang W.L., Lo F-Y., Whitehead K., Koide T., Masumura K., Pan M., Kaur A., Larsen D.J., Reiss D.J., Hoang L., Kalisiak E., Northen T., Trauger S.A., Siuzdak G., Baliga N.S.
Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive system analysis
BMC Systems Biology, 2010 4 64      PDF Link           PMID: 20470417     PMC2880973
160 Cvetkovic A., Menon A.L., Thorgersen M.P., Scott J.W., Poole F.L. II, Jenney F.E. Jr., Lancaster W.A., Praissman J.L., Shanmukh S., Vaccaro B.J., Trauger S.A., Kalisiak E., Apon J.V., Siuzdak G., Yannone S.M., Tainer J.A., Adams M.W.W.
Microbial metalloproteomes are largely uncharacterized
Nature, 2010 466 779-784      PDF File           PMID: 20639861     
159 Lowe R., Szili E., Kirkbride P., Thissen H., Siuzdak G., Voelcker N.
Combined Immunocapture and Laser Desorption/Ionization Mass Spectrometry on Porous Silicon
Analytical Chemistry, 2010 82(10) 4201-8      PDF Link           PMID: 20411919     
158 Dorrell M.I., Aguilar E., Jacobson R., Trauger S.A., Friedlander J., Siuzdak G., Friedlander
Maintaining Retinal Astrocytes Normalizes Revascularization and Prevents Vascular Pathology Associated with Oxygen-Induced Retinopathy
Glia, 2010 58(1) 43-54      PDF File           PMID: 19544395     PMC2814838
157 Pendyala G., Trauger S.A., Siuzdak G., Fox H.S.
Quantitative Plasma Proteomic Profiling Identifies the Vitamin E Binding Protein Afamin as a Potential Pathogenic Factor in SIV Induced CNS Disease
J Proteome Res., 2010 9(1) 352-358      PDF File           PMID: 19908921     PMC2801767
156 Dorrell M.I., Aguilar E., Jacobson R., Yanes O., Gariano R., Heckenlively J., Banin E., Ramirez G.A., Gasmi M., Bird A., Siuzdak G., Friedlander M.
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress
J. Clin. Invest., 2009 119(3) 611-623                 PMID: 19188685     PMC2648679
155 Zhou H.Y., Wu S.L., Joo J.Y., Zhu S.Y., Han D.W., Lin T.X., Trauger S., Bien G., Yao S., Zhu Y., Siuzdak G., Scholer H.R., Duan L.X., Ding S.
Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins
Cell Stem Cell, 2009 4(6) 581-581      PDF File           PMID: 19398399     
154 Pendyala G., Trauger S.A., Kalisiak E., Ellis R.J., Ciborowski P., Gendelman H.E., Siuzdak G., Fox H.S.
Proteomic Profiling of Cerebrospinal Fluid Reveals Potential Neuropathogenic Changes in neuroAIDS
Journal of Neurovirology, 2009 15 72-73                      
153 Woo H.K., Go E.P., Hoang L., Trauger S.A., Bowen B., Siuzdak G., Northen T.R.
Phosphonium labeling for increasing metabolomic coverage of neutral lipids using electrospray ionization mass spectrometry
Rapic Communications in Mass Spectrometry, 2009 23(12) 1849-1855      PDF File           PMID: 19449318     PMC3052201
152 Crews B., Wikoff W.R., Patti G.J., Woo H.K., Kalisiak E., Heideker J., Siuzdak G.
Variability analysis of human plasma and cerebral spinal fluid reveals statistical significance of changes in mass spectrometry-based metabolomics data
Anal Chem, 2009 81(20) 8538-44      PDF File           PMID:19764780     PMC3058611
151 Kalisiak J., Trauger S., Kalisiak E., Morita H., Fokin V., Adams M.M., Sharpless K.B., Siuzdak G.
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach
J. Am. Chem. Soc., 2009 131(1) 378-386      PDF File           PMID: 19055353     PMC2735399
150 Yanes O., Woo H-H., Northen T.R., Oppenheimer S.R., Schriver L., Apon J., Estrada M.N., Potchoiba M.J., Steenwyk R., Manchester M., Siuzdak G.
Nanostructure Initiator Mass Spectrometry: Tissue Imaging and Direct Biofluid Analysis
Anal Chem, 2009 81(8) 2969-75      PDF File           PMID: 19301920     PMC2676195
149 Wikoff W.R., Anfora A.T., Liu J.W., Shultz P.G., Lesley S.A., Peters E.C., Siuzdak G.
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Proc Natl Sci USA, 2009 106(10) 3698-703      PDF File           PMID: 19234110     PMC2656143
148 Wikoff W.R., Kalisiak E., Trauger S., Manchester M., Siuzdak G.
Response and recovery in the plasma metabolome tracks the acute LCMV-induced immune response
J Proteome Res, 2009 8(7) 3578-87      PDF File           PMID: 19496611     PMC3437991
147 Koudelka K.J., Destito G., Plummer E.M., Trauger S.A., Siuzdak G., Manchester M.
Endothelial Targeting of Cowpea Mosaic Virus (CPMV) via Surface Vimentin
Plos Pathogens, 2009 5(5) e1000417      PDF File           PMID:19412526     PMC2670497
146 Pendyala G., Trauger S.A., Kalisiak E., Ellis R.J., Siuzdak G., Fox H.S.
Cerebrospinal Fluid Proteomics Reveals Potential Pathogenic Changes in the Brains of SIV-Infected Monkeys
Journal of Proteome Research, 2009 8(5) 2253-2260      PDF File           PMID:19281240     PMC2682714
145 Menon A.L., Poole F.L., Cvetkovic A., Trauger S.A., Kalisiak E., Scott J.W., Shanmukh S., Praissman J., Jenney F.E., Wikoff W.R., Apon J.V., Siuzdak G., Adams M.W.W.
Novel Multiprotein Complexes Identified in the Hyperthermophilic Archaeon Pyrococcus furiosus by Non-denaturing Fractionation of the Native Proteome
Molecular and Cellular Proteomics, 2009 8(4) 735-751      PDF File           PMID: 19043064     PMC2668238
144 Ivey R.M., Gentle Jr. T.M.. Moore R.L., Towns M.L., Bachur Jr. N., Rosenstein R.W., Nadeau J.G., Goldenbaum P.E., Shi S., Copertino D., Garrett J., Tice G., Siuzdak G., Want E., Shen Z.
Method of predicting the onset of sepsis in IRS-positive individuals using mass spectrometry
Patent #7,632,685, 2009                      
143 Bunner A.E., Trauger S.A., Siuzdak G., Williamson J.R.
Quantitative ESI-TOF Analysis of Macromolecular Assembly Kinetics
Analytical Chemistry, 2008 80(24) 9379-9386      PDF File           PMID: 19007188     PMC2735594
142 Benton H.P., Wong D.M., Siuzdak G.
XCMS2: Processing Tandem Mass Spectrometry Data for Metabolite Identification and Structural Characterization
Analytical Chemistry, 2008 80(16) 6382-6389      PDF File           PMID: 18627180     PMC2728033
141 Woo H.K., Northen T.R., Yanes O., Siuzdak G.
Nanostructure-initiator mass spectrometry: a protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis
Nature Protocols, 2008 3(8) 1341-1349                 PMID: 18714302     
140 Wikoff W.R., Pendyala G., Siuzdak G., Fox H.S.
Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques
Journal of Clinical Investigation, 2008 118(7) 2661-2669      PDF File           PMID: 18521184     PMC2398736
139 Northen T.R., Lee J-C, Hoang L., Raymond J., Hwang D-R, Yannone S.M., Wong C-H, Siuzdak G.
A Nanostructure-Initiator Mass Spectrometry-Based Enzyme Activity Assay
PNAS, 2008 105(10) 3678-3683      PDF File           PMID: 18319341     PMC2268803
138 Nordstrom A. Want E., Northen T., Lehtio J., Siuzdak G.
Multiple Ionization Mass Spectrometry Strategy Reveals the Complexity of Metabolomics
Analytical Chemistry, 2008 80 421-429      PDF File           PMID: 18085752     
137 Trauger S.A., Kalisiak E., Kalisiak J., Morita H., Weinbergb M.V., Menon A.L., Poole F.L. II, Adams M.W.W., Siuzdak G.
Correlating the Transcriptome, Proteome, and Metabolome in the Environmental Adaptation of a Hyperthermophile
Journal of Proteome Research, 2008 7 1027-1035      PDF File           PMID: 18247545     
136 O'Maille G., Go E.P., Hoang L., Want E.J., Smith C., O'Maille P., Nordstrom A., Morita H., Qin C., Uritboonthai W., Apon J., Moore R., Garrett J., Siuzdak G.
Metabolomics relative quantitation with mass spectrometry using chemical derivatization and isotope labeling
Spectroscopy - An International Journal, 2008 22(5) 327-343      PDF File                
135 Vallon V., Eraly S.A., Wikoff W.R., Rieg T., Kaler G., Truong D.M., Ahn S-Y., Mahapatra N.R., Mahata S.K., Gangoiti J.A., Wu W., Barshop B.A., Siuzdak G., Nigam S.K.
Organic anion transporter 3 contributes to the regulation of blood pressure
Journal of the American Society of Nephrology, 2008 19(9) 1732-1740      PDF File           PMID: 18508962     PMC2518443
134 Northen T.R., Yanes O., Northen M.T., Marrinucci D., Uritboonthai W., Apon J., Golledge S.L., Nordstrom A., Siuzdak G.
Clathrate nanostructures for mass spectrometry
Nature, 2007 449(7165) 1033-U3      PDF Link           PMID: 17960240     
133 Wikoff W.R., Gangoitti J.A., Barshop B.A., Siuzdak G.
Metabolomics identifies perturbations in human disorders of propionate metabolism
Clinical Chemistry, 2007 53(12) 2169-2176      PDF Link           PMID: 17951291     
132 Go E.P., Uritboonthai W., Apon J.A., Trauger S.A., Nordstrom A., O'Maille G., Brittain S., Peters E.C., Siuzdak G.
Selective Metabolite and Peptide Capture/Mass Detection Using Fluorous Affinity Tags
Journal of Proteome Research, 2007 6 1492-1499      PDF File           PMID: 17343404     
131 Cohen L., Go E.P. , Siuzdak G.
Small Molecule Desorption/Ionization Mass Analysis
MALDI-MS Franz Hillenkamp - editor, 2007 IX 299      PDF File                
130 Nordstrom A., He L., Siuzdak G.
Desorption/Ionization on Silicon (DIOS)
Encyclopedia of Mass Spectrometry, Editor Michael Gross, 2007 6 676-683      PDF File                
129 Northen T.R., Woo H.K., Northen M.T., Nordstrom A., Uritboonthai W., Turner K., Siuzdak G.
High Surface Area of Porous Silicon Drives Desorption of Intact Molecules
J. Am. Soc. Mass Spectrom., 2007 18(11) 1945-1949      PDF File           PMID: 17881245     PMC2080661
128 Pendyala G., Want E.J., Webb W., Siuzdak G., Fox H.S.
Biomarkers for NeuroAIDS: The widening scope of Metabolomics
Journal of NeuroImmune Pharmacology, 2007 2 72-80      PDF File           PMID: 18040828     
127 Want E.J., Nordstrom A., Morita H., Siuzdak G.
From Exogenous to Endogenous: The Inevitable Imprint of Mass Spectrometry in Metabolomics
Journal of Proteome Research, 2007 6(2) 459-468      PDF File           PMID:17269703     
126 Mutch D.M., O'Maille G., Wikoff W., Wiedmer T., Sims P.J., Siuzdak G.
Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice
Genome Biology, 2007 8 R38      PDF File           PMID: 17355638     PMC1868938
125 Wikoff W.R., Gangoiti J.A., Barshop B.A., Siuzdak G.
Metabolomics identifies perturbations in human disorders of propionate metabolism
Clin Chem, 2007 53(12) 2169-76                 PMID: 17951291     
124 Chace D.H., Barr J.R., Duncan M.W., Matern D., Morris M.R., Palmer-Toy D.E., Rockwood A.L., Siuzdak G., Urbani A., Yergey A.L., Chan Y.M.
Mass Spectrometry in the Clinical Laboratory: General Principles and Guidance
Clinical and Laboratory Standards Institute, 2007 27 1-91                      
123 Lissauer M., Johnson S.B., Siuzdak G., Bochicchio G., Whiteford C., Nussbaumer W., Moore R., Scalea T.S.
Coagulation and Complement Protein Differences Between Septic and Uninfected SIRS Patients
The Journal of Trauma, Injury, Infection and Critical Care, 2007 62(5) 1080-1094      PDF File           PMID: 17495706     
122 Nordstrom A., Apon J.V., Uritboonthai W., Go E.P., Siuzdak G.
Surfactant Enhanced Desorption/Ionization on Silicon (DIOS) Mass Spectrometry
Analytical Chemistry, 2006 78 272-278      PDF File           PMID: 16383337     
121 Want E.J., O'Maille G., Smith C.A., Brandon T.R., Uritboonthai W., Qin C., Trauger S.A., Siuzdak G.
Solvent-Dependent Metabolite Distribution, Clustering and Protein Extraction for Serum Profiling with Mass Spectrometry
Analytical Chemistry, 2006 78 743-752      PDF File           PMID: 16448047     
120 Siuzdak G.
The Expanding Role of Mass Spectrometry in Biotechnology - 2nd Edition
MCC Press, San Diego, 2006 III 1-252                      
119 Smith C.A., Want E.J., O'Maille G., Abagyan R., Siuzdak G.
XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching and identification
Analytical Chemistry, 2006 78 779-787      PDF File           PMID: 16448051     
118 Want E.J., Smith C., Siuzdak G.
Phospholipid Capture Combined with Non-Linear Chromatographic Correction for Improved Metabolite Profiling
Metabolomics, 2006 2 145-154      PDF File                
117 Shen Z., Want E.J., Chen W., Keating W, Nussbaumer W, Moore R, Gentle T.M., Siuzdak G.
Sepsis Plasma Protein Profiling with Immunodepletion, Three-Dimensional Liquid Chromatography Tandem Mass Spectrometry and Spectrum Counting
Journal of Proteome Research, 2006 5 (11) 3154 - 3160      PDF File           PMID:17081067     
116 Lee J-C.,Wu C-Y., Apon J.V., Siuzdak G., Wong C-H.
Reactivity-Based One-Pot Synthesis of Tumor-Associated Antigen N3 Minor Octasaccharide: A Case Study of DIOS-MS Sugar Array**
Angew Chem Int Ed, 2006 45 2753 - 2757      PDF File           PMID: 16548041     
115 Go E.P., Wikoff W., Shen Z., O'Maille G., Morita H., Conrads T.P., Nordstrom A., Trauger S.A., Uritboonthai W., Lucas D., Chan K.C., Veenstra T.D., Lewicki H., Oldstone M.B., Schneemann A., Siuzdak G.
Mass Spectrometry Reveals Specific and Global Molecular Transformations during Viral Infection
Journal of Proteome Research, 2006 5 (9) 2405 - 2416      Related Page           PMID:16944953     PMC2566936
114 Nordstrom A., O'Maille G., Qin C., Siuzdak G.
Non-linear Data Alignment for UPLC-MS and HPLC-MS based Metabolomics: Quantitative Analysis of Endogenous and Exogenous Metabolites in Human Serum
Analytical Chemistry, 2006 78 7289-3295      PDF File           PMID: 16689529     PMC3705959
113 Steenwyk R., Hutzler J.M., Sams J., Shen Z., Siuzdak G.
Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1'-hydroxylation kinetics in human liver microsomes.
Rapid Communication in Mass Spectrometry, 2006 20 3717-3722      PDF File           PMID: 17117443     
112 Smith C.A., O'Maille G., Want E.J., Qin C., Trauger S.A., Brandon T.R., Custodio D.E., Abagyan R., Siuzdak G.
METLIN: a metabolite mass spectral database
Therapeutic Drug Monitoring, 2005 27(6) 747-751      PDF File           PMID: 16404815     
111 Lowe R., G E., Tong G., Voelcker N.H., Siuzdak G.
Monitoring EDTA and endogenous metabolite from serum with mass spectrometry
Spectroscopy, 2005 19(13) 137-146      PDF File                
110 Friedlander M.H., Mehra P.K., Siuzdak G., Stevenson D.D.
Ocular Reactions During Aspirin Challenge in Aspirin-Exacerbated Respiratory Disease
Investigative Ophthalmology & Visual Science, 2005 46(Sup. S) 943      Related Page                
109 Lacy E.R., Wang Y., Post J., Nourse A., Webb W., Mapelli M., Musacchio A., Siuzdak G., Kriwacki R.
Molecular Basis for the Specificity of p27 Toward Cyclin-dependent Kinases that Regulate Cell Division
Journal of Molecular Biology, 2005 349 764-773                      
108 Bothner B., Taylor D., Jun B., Lee K., Siuzdak G., Schultz C.P., Johnson J.
Maturation of a tetravirus capsids alters the dynamic properties and creates a metastable complex
Virology, 2005 334 17-27      PDF File           PMID:15749119     
107 Go E.P., Apon J.V., Luo G., Saghatelian A., Daniels R.H., Sahi V., Cravatt B., Vertes A., Dubrow R., Siuzdak G.
Desorption/ionization on silicon nanowires
Analytical Chemistry, 2005 77 1641-6      PDF File           PMID:15762567     
106 Want E., Cravatt B.F., Siuzdak G.
The Expanding Role of Mass Spectrometry in Metabolite Profiling and Characterization
ChemBioChem, 2005 6 1941-1951      PDF File           PMID:16206229     
105 Talkington M.T., Siuzdak G., Williamson J.R.
An assembly landscape for the 30S ribosomal subunit
Nature, 2005 438 628-632      PDF File           PMID: 16319883     PMC1444899
104 Luo G., Chen Y., Siuzdak G., Vertes A.
Surface Modification and Laser Pulse Length Effects on Internal Energy Transfer in DIOS
Journal of Physical Chemistry B, 2005 109 24450-24456      PDF File           PMID: 16375447     
103 Siuzdak G.
An Introduction to Mass Spectrometry Ionization
Journal of the Association of Lab Automation, 2004 9(2) 50-63      PDF File                
102 Shen Z., Thomas J.J., Siuzdak G., Blackledge R.D.
A case study on forensic polymer analysis by DIOS-MS: the suspect who gave us the SLIP
Journal of Forensic Science, 2004 49 1-8      PDF File           PMID:15461106     
101 Meng J.-C., Siuzdak G., Finn M.G.
Affinity Mass Spectrometry from a Tailored Porous Silicon Surface
Chemical Communications, 2004 18 2108-2109      PDF File           PMID:15367998     
100 Kriwacki R., Reisdorph N., Siuzdak G.
Protein Structure Characterization with Mass Spectrometry
Spectroscopy, 2004 18 37-47      PDF File                
99 Wu, E., Trauger, S.A., Pache, L., Mullen, T.-M., Von Seggern, D.J., Siuzdak, G., Nemerow, G.R.
Membrane Cofactor Protein (MCP: CD46) is a Receptor for Adenoviruses Associated with Epidemic Keratoconjunctivitis
Journal of Virology, 2004 78 3897-3905      PDF File           PMID: 15047806     PMC374279
98 Meng J.-C., Averbuj C., Siuzdak G., Finn M.G.
Cleavable Linkers for Porous Silicon-Based Mass Spectrometry
Angewandte Chemie, 2004 43 1255-1260      PDF File           PMID: 14991792     
97 Bothner B., Siuzdak G.
Electrospray Ionization of a Whole Virus: Analyzing Mass, Structure and Viability
ChemBioChem, 2004 5(3) 258-260      PDF File           PMID: 14997515     
96 Shen Z., Go E.P., Gamez A., Apon J.V., Fokin V., Greig M., Ventura M., Crowell J.E., Blixt O., Paulson J.C., Stevens R., Finn M.G., Siuzdak G.
A Mass Spectrometry Plate Reader: Monitoring Enzyme and Inhibitor Activity with Desorption/Ionization on Silicon (DIOS) Mass Spectrometry
ChemBioChem, 2004 5 921-927      PDF File           PMID: 15239048     
95 Thomas J.J., Bothner B., Traina J., Benner W.H., Siuzdak G.
Electrospray Ion Mobility Spectrometry of Intact Viruses
Spectroscopy, 2004 18 31-36      PDF File                
94 Trauger S., Go E.P., Shen Z., Apon J.V., Compton B., Bouvier E.S.P., Finn M.G., Siuzdak G.
High Sensitivity and Analyte Capture with Desorption/Ionization Mass Spectrometry on Silylated Silicon
Analytical Chemistry, 2004 76 4484-4489      PDF File           PMID: 15283591     
93 Trauger S.A., Wu E., Bark S.B., Nemerow G.R., Siuzdak G.
The Identification of an Adenovirus Receptor by Using Affinity-Capture and Mass Spectrometry
ChemBioChem, 2004 5(8) 1095-1099      PDF File           PMID:15300833     
92 Saghatelian A., Trauger S.A., Want E., Hawkins G., Siuzdak G., Cravatt B.F.
Assignment of Endogenous Substrates to Enzyme by Global Metabolite Profiling
Biochemistry, 2004 43 14332-14339      PDF File           PMID: 15533037     
91 Want E.J., Greig M., Compton B.J., Bola?os B., Siuzdak G.
Mass Spectrometry in High Throughput Analysis
Spectroscopy, 2003 17 663-680      PDF File                
90 Want E., Compton B.J., Hollenbeck T., Siuzdak G.
The Application of Mass Spectrometry in Pharmacokinetics
Spectroscopy, 2003 17 681-691      PDF File                
89 Siuzdak G.
The Expanding Role of Mass Spectrometry in Biotechnology
MCC Press: San Diego, 2003                      
88 Prenni J.E., Shen Z., Trauger S., Chen W., Siuzdak G.
Protein Characterization using Liquid Chromatography Desorption Ionization on Silicon Mass Spectrometry (LC-DIOS-MS)
Spectroscopy, 2003 17 693-698      PDF File                
87 Compton B.J., Siuzdak G.
Mass Spectrometry in Nucleic Acid, Carbohydrate, and Steroid Analysis
Spectroscopy, 2003 17 699-713      PDF File                
86 Barker, G., Want, E., Boydston, J., Siuzdak, G.
Mass Spectrometry
Science of Synthesis/ Houben-Weyl, 2003 7.6 680-695      PDF File                
85 Lewis W., Shen Z., Finn M.G., Siuzdak G.
Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications
International Journal of Mass Spectrometry, 2003 226 107-116      PDF File                
84 Meyers A., Trauger S., Webb W., Reisdorph N., Wranik C., Peters E., Siuzdak G.
Protein Profiling with Mass Spectrometry
Spectroscopy, 2003 17 1-15                      
83 Yao S., Meng J., Siuzdak G., Finn M.G.
New Catalysts for Asymmetric Hydrosilylation of Ketones Discovered by Parallel Mass Screening
Journal of Organic Chemistry, 2003 68 2540-2546      PDF File                
82 Trauger S.A., Junker T., Siuzdak G.
Investigating Viral Proteins and Intact Viruses with Mass Spectrometry
Modern Mass Spectrometry, 2003 225 265-282      PDF File                
81 Go E.P., Prenni J.E., Wei J., Jones A., Hall S.C., Witkowska E., Shen Z., Siuzdak G.
Desorption/Ionization on Silicon Time-of-Flight/Time-of-Flight (DIOS-TOF/TOF) Mass Spectrometry
Anal. Chem., 2003 75 2504-2506      PDF File           PMID:12918997     
80 Borman S., Russell H., Siuzdak G.
A Mass Spectrometry Timeline
Today's Chemist, 2003 47-49      PDF File                
79 Reisdorph N., Thomas J.J., Katpally U., Chase E., Harris K., Siuzdak G., Smith T.J.
Human Rhinovirus Capsid Dynamics is Controlled by Canyon Flexibility
Virology, 2003 314 34-44      PDF File           PMID: 14517058     
78 Go E.P., Shen Z., Harris K., Siuzdak G.
Quantitative Analysis with Desorption/Ionization on Silicon (DIOS) Mass Spectrometry using Electrospray Deposition
Analytical Chemistry, 2003 75 5475-5479      PDF File           PMID: 14710827     
77 Sonderegger M., Staniszewski K., Meyers A., Siuzdak G.
A Bioinformatics Approach for Mass Spectrometry Data Processing: Applications to Proteomics and Small Molecule Analysis
Spectroscopy, 2002 16 81-87      PDF File                
76 Shen Z., Yao S., Crowell J., Siuzdak G., Finn M.G.
DIOS-MSEED: A Chip-Based Method for Measurement of Enantiomeric Excess by Kinetic Resolution/Mass Spectrometry
Israel Journal of Chemistry special issue commemorating Wolf Prize to Sharpless, Kagan and Noyori, 2002 41 313-316      PDF File                
75 Grayson M. Editor, Siuzdak G.
Contributor-Biological Mass Spectrometry Measuring Mass: From Positive Rays to Proteins
Chemical Heritage Press, 2002 149                      
74 Bothner B., Carmitchel L., Staniszewski K., Sonderegger M., Siuzdak G.
Biomolecule Structure Characterization in the Gas Phase using Mass Spectrometry
Spectroscopy, 2002 16 71-79      PDF File                
73 Smith T.J., Schmidt T., Fang J., Wu J., Siuzdak G., Stanley C.
The Structure of Apo Human Glutamate Dehydrogenase Elucidates the Mechanism of Subunit Communication and the Hyerinsulinism/Hyperammonemia Syndrome
Journal of Molecular Biology, 2002 318 765-777      PDF File                
72 Trauger S.A., Webb W., Siuzdak G.
Peptide and Protein Analysis with Mass Spectrometry
Spectroscopy, 2002 16 15-28      PDF File                
71 Thomas J.J., Blackledge R.D., Siuzdak G.
Desorption-Ionization on Silicon Mass Spectrometry: An Application in Forensics
Analytica Chemica Acta, 2001 442 183-190      PDF File                
70 Shen Z., Thomas J.J., Averbuj C., Broo K.M., Engelhard M., Crowell J.E., Finn M.G., Siuzdak G.
Porous Silicon as a Versatile Platform for Laser Desorption/Ionization Mass Spectrometry
Analytical Chemistry, 2001 73(3) 612-619      PDF File           PMID:11217770     
69 Broo K.M., Wei J., Marshall D., Brown F., Smith T.J., Johnson J.E., Schneemann A., Siuzdak G.
Viral Capsid Mobility: A Dynamic Conduit for Inactivation
Proceedings of the National Academy of Sciences, 2001 98 2274-2277      PDF File           PMID: 11226229     PMC30128
68 Thomas J.J., Shen Z., Crowell J.E., Finn M.G., Siuzdak G.
Desorption/Ionization on Silicon (DIOS): A Diverse Mass Spectrometry Platform for Protein Characterization
Proceedings of the National Academy of Sciences, 2001 98 4932-4937      PDF File           PMID: 11296246     PMC33141
67 Bark S.J., Muster N., Yates J.R., Siuzdak G.
High-Temperature Protein Mass Mapping Using a Thermophilic Protease
Journal of the American Chemical Society, 2001 123 1774-1775      PDF File           PMID: 11456785     
66 Fuerstenau S.D., Benner W.H., Thomas J.J., Brugidou C., Bothner B., Siuzdak G.
Mass Spectrometry of an Intact Virus
Angewandte Chemie, 2001 40 542-544      PDF File           PMID: 11180363     
65 Kriwacki R., Siuzdak G.
Probing Protein/Protein Interactions with Mass Spectrometry
Methods in Molecular Biology Humana Press, 2000      PDF File           PMID:10948505     
64 Thomas J.J., Bakhtiar R., Siuzdak G.
Mass Spectrometry in Viral Proteomics
Accounts of Chemical Research, 2000 33 179-187      PDF File           PMID:10727207     
63 Lewis J.K., Wei J., Siuzdak G.
MALDI Mass Spectrometry in Protein and Peptide Analysis
Encyclopedia of Analytical Chemistry, John Wiley and Sons, NY, 2000      PDF File                
62 Bothner B., Chavez R., Wei J., Strupp C., Phung Q., Schneemann A., Siuzdak G.
Monitoring Enzyme Catalysis with Mass Spectrometry
Journal of Biological Chemistry, 2000 275 13455-13459      PDF File           PMID: 10788458     
61 Guo J., Wu J., Siuzdak G., Finn M.G.
Measurement of Enantiomeric Excess by Kinetic Resolution and Mass Spectrometry
Angewandte Chemie Int. Ed., 1999 38 1755-1758      PDF File                
60 Schalley C.A., Rivera J.M., Martin T., Santamaria J., Siuzdak G., Rebek, J. Jr.
Structural Examination of Supramolecular Architectures by Electrospray Ionization Mass Spectrometry
Eur. J. Org. Chem., 1999 1325-1331      PDF File                
59 Schalley C.A., Castellano R.K., Brody M.S., Rudkevich D.M., Siuzdak G., Rebek J.
Investigating Molecular Recognition by Mass Spectrometry: Characterization of Calixarene-Based Self-Assembling Capsule Hosts with Charged Guests
J. Am. Chem. Soc., 1999 121(19) 4568-4579      PDF File                
58 Hollenbeck T., Siuzdak G., Blackledge R.D.
Electrospray and MALDI Mass Spectrometry in the Identification of Spermicides in Criminal Investigations
Journal of Forensic Sciences, 1999 44 783-788      PDF File           PMID: 10432613     
57 Takayama S., Chung S.J., Igarashi Y., Ichikawa Y., Sepp A., Lechler R.I., Wu J.Y. Hayashi T., Siuzdak G., Wong C.H.
Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferases: Donor sugar-nucleotide based approach
Bioorganic & Medicinal Chemistry, 1999 7 401-409      PDF File           PMID: 10218835     
56 Tsui V., Garcia C., Cavagnero S., Siuzdak G., Dyson H.J., Wright P.E.
Quench-Flow Experiments Combined with Mass Spectrometry Show Apomyoglobin Folds through an Obligatory Intermediate
Protein Science, 1999 8 45-49      PDF File           PMID:10210182     PMC2144105
55 Marmey P., Bothner B., Jacquot E., de Kochko A., Ong C.A., Yot P., Siuzdak G., Beachy R.N., Fauquet C.
Rice Tungro Bacilliform Virus Open Reading Frame 3 Encodes a Single 37-kDa Coat Protein
Virology, 1999 253 319-326      PDF File           PMID: 9918890     
54 Siuzdak G.
Innovations Continue in Mass Spectrometry
Advance, 1999 8(1) 30-34      PDF File                
53 Siuzdak G., Hollenbeck T., Bothner B.
Preparative mass spectrometry with electrospray ionization
Journal of Mass Spectrometry, 1999 34 1087-1088      PDF File           PMID:10510432     
52 Chatman K.S., Hollenbeck T., Hagey L., Vallee M., Purdy R., Weiss F., Siuzdak G.
Nanoelectrospray Mass Spectrometry and Precursor Ion Monitoring for Quantitative Steroid Analysis and Attomole Sensitivity
Analytical Chemistry, 1999 71 2358-2363      PDF File           PMID:10405603     
51 Siuzdak G.
Mass Spectrometry
in The Encyclopedia of Molecular Biology T.E. Creighton, Ed., John Wiley & Sons, Inc., New York, NY, 1999                      
50 Bothner B., Schneemann A., Marshall D., Reddy V., Johnson J.E., Siuzdak G.
Crystallographically Identical Virus Capsids Display Different Properties in Solution
Nature Structural Biology, 1999 6 114-116      PDF File           PMID: 10048920     
49 Lewis J.K., Chiang J., Siuzdak G.
Monitoring Protein-Drug Interactions with Mass Spectrometry and Proteolysis Protein Mass Mapping as a Drug Assay
Journal of the Association for Laboratory Automation, 1999 4 46-48      PDF File                
48 Yang C., Gu Z., Yang M., Lin S., Siuzdak G., Smith C.V.
Identification of Modified Tryptophan Residues in Apolipoprotein B-100 Derived from Copper Ion-Oxidized Low-Density Lipoprotein
Biochemistry, 1999 38 15903-15908      PDF File           PMID: 10625456     
47 Wei J., Buriak J., Siuzdak G.
Desorption-ionization mass spectrometry on porous silicon
Nature, 1999 399(6733) 243-246      PDF File           PMID: 10353246     
46 Siuzdak G., Buriak J., Wei J.
Improved Methods for Laser Desorption from Porous Semiconductors
patent #6, 1999 288 390                      
45 Siuzdak G.
Probing Molecular Diversity with Mass Spectrometry
Journal of the Association for Laboratory Automation, 1998 3(2) 34-37      PDF File                
44 Niece, R., Siuzdak, G.
Joint ABRF/ASBMB Symposium: Present and Future of Biomolecular Mass Spectrometry
Journal of Biomolecular Techniques, 1998 9 22-23                      
43 Owens D.R., Bothner B., Harris K., Phung Q., Siuzdak G.
Aspects of Oligonucleotide and Peptide Sequencing with MALDI and Electrospray Mass Spectrometry
Bioorganic and Medicinal Chemistry, 1998 6 1547-1554      PDF File           PMID: 9801826     
42 Siuzdak G.
Probing Viruses with Mass Spectrometry
Journal of Mass Spectrometry, 1998 33(3) 203-211      PDF File           PMID: 9538522     
41 Bothner B., Dong X.F., Bibbs L., Johnson J.E., Siuzdak G.
Evidence of Viral Capsid Dynamics Using Limited Proteolysis and Mass Spectrometry
Journal of Biological Chemistry, 1998 273(2) 673-676      PDF File           PMID: 9422714     
40 Siuzdak G., Lewis J.K.
Applications of mass spectrometry in combinatorial chemistry
Biotechnology & Bioengineering with Combinatorial Chemistry, 1998 61(2) 127-134      PDF File           PMID: 10099506     
39 Siuzdak G., Henriksen S.
New Directions in the Analysis of Brain Substances Related to Sleep and Wakefulness
Lydic, R. CRC Press, Methods in the Life Sciences Series; Molecular regulation of arousal states., 1998 181-190      PDF File                
38 Lewis J.K., Bothner B., Smith T.J., Siuzdak G.
Antiviral Agent Blocks Breathing of Common Cold Virus
Proceedings of the National Academy of Sciences, USA, 1998 95(12) 6774-6778      PDF File           PMID: 9618488     PMC22631
37 Lewis J.K., Bendahmane M., Smith T.J., Beachy R.N., Siuzdak G.
Identification of viral mutants by mass spectrometry
Proceedings of the National Academy of Sciences, USA, 1998 95 8596-8601      PDF File           PMID: 9671723     PMC21121
36 Kriwacki R., Siuzdak G.
Combined Use of Proteases and Mass Spectrometry in Structural Biology
Journal of Biomolecular Techniques, 1998 9 5-15      PDF File                
35 Kriwacki R., Wu J., Tennant L., Wright P.E., Siuzdak G.
Probing Protein Structure Using Biochemical and Biophysical Methods: Proteolysis, Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, High-Performance Liquid Chromatography and Size Exclusion Chromatography of p21graphy of p21Waf1/Cip1/Sdi1
Journal of Chromatography A, 1997 777 23-30      PDF File           PMID: 9297835     
34 Takayama S., Martin R., Wu J., Laslo K., Siuzdak G., Wong C.H.
Chemoenzymatic Preparation of Novel Cyclic Imine Sugars and Rapid Biological Activity Evaluation Using Electrospray Mass Spectrometry and Kinetic Analysis
Journal of the American Chemical Society, 1997 119(35) 8146-8151      PDF File                
33 Wu J., Chatman K.S., Harris K., Siuzdak G.
An Automated MALDI Mass Spectrometry Approach for Optimizing Cyclosporin Analysis
Analytical Chemistry, 1997 69(18) 3767-3771      PDF File           PMID: 9302875     
32 Wu J., Takayama S., Wong C.H., Siuzdak G.
Quantitative Electrospray Mass Spectrometry for the Rapid Assay of Enzyme Inhibitors
Chemistry & Biology, 1997 4(9) 653-657      PDF File           PMID: 9331404     
31 Siuzdak G.
Mass Spectrometry for Biotechnology
Academic Press: San Diego, CA, 1996 161                      
30 Fitzgerald M.C., Siuzdak G.
Biochemical Mass Spectrometry: Worth the Weight?
Chemistry and Biology, 1996 3 707-715      PDF File           PMID: 8939685     
29 Kriwacki R., Wu J., Siuzdak G., Wright P.E.
Probing Protein-Protein Interactions by Mass Spectrometry: Analysis of the p21/Cdk2 Complex
Journal of the American Chemical Society, 1996 118 5320-5321      PDF File                
28 Fitzgerald M.C., Harris K., Shevlin C.G., Siuzdak G.
Direct Characterization of Solid Phase Resin-Bound Molecules by Mass Spectrometry
Bioorganic and Medicinal Chemistry Letters, 1996 6(8) 979-982      PDF File                
27 Siuzdak G., Bothner B., Yeager M., Brugidou C., Fauquet C.M., Hoey K., Chang C.M.
Mass Spectrometry and Viral Analysis
Chemistry & Biology, 1996 3 45      PDF File                
26 Lerner R.A., Cravatt B., Boger D.L., Siuzdak G. and Henriksen S.
Method for Sleep Induction
international PCT patent application WO 96/09817, 1996                      
25 Chang H.T., Chen C.T., Kondo T., Siuzdak G., and Sharpless K.B.
Asymmetric Dihydroxylation Enables Rapid Construction of Chiral Dendrimers based on 1,2-Diols
Angewandte Chemie, 1996 35(2) 182-186      PDF File                
24 Bothner B., Chatman K.S., Sarkisian M., Siuzdak G.
Liquid Chromatography Mass Spectrometry of Antisense Oligonucleotides
Bioorganic and Medicinal Chemistry Letters, 1995 5(23) 2863-2868      PDF File                
23 Siuzdak G., Bothner B.
Gas-Phase Micelles
Angewandte Chemie, 1995 34(18) 2053-2055      PDF File                
22 Cravatt B., Prospero-Garcia O., Siuzdak G., Gilula N.B., Henriksen S.J., Boger D.L., Lerner R.A.
Chemical Characterization of a Family of Brain Lipids with Sleep Inducing Potential
Science, 1995 268 1506-1509      PDF File                
21 Krebs J.F., Siuzdak G., Dyson H.J., Stewart J.D., Benkovic S.
Detection of a Catalytic Antibody Species Acylated at the Active Site by Electrospray Mass Spectrometry
Biochemistry, 1995 34 720-723      PDF File           PMID:7827028     
20 Siuzdak G., Zheng Y.L., Ramphal J.Y., Ichikawa Y., Nicolaou K.C., Gaeta F.C.A., Chatman K.S., Wong C.H.
Examination of the Sialyl Lewis X- Calcium Complex by Electrospray Mass Spectrometry
Bioorganic and Medicinal Chemistry Letters, 1994 4 2863-2866      PDF File                
19 Siuzdak G.
The emergence of mass spectrometry in biochemical research
Proceedings of the National Academy of Sciences of the United States of America, 1994 91 11290-11297      PDF File           PMID:7972052     PMC45217
18 Lerner R.A., Siuzdak G., Prospero-Garcia O., Henriksen S.J., Boger D.L., Cravatt B.
Cerebrodiene: A Brain Lipid Isolated from Sleep-Deprived Cats
Proceedings of the National Academy of Sciences of the United States of America, 1994 91 9505-9508                      
17 Stewart J.D., Krebs J.F., Siuzdak G., Berdis A.J., Smithrud D.B., Benkovic S.J.
Dissection of an Antibody-Catalyzed Reaction
Proc. Natl. Acad. Sci., 1994 91 7404-7409      PDF File           PMID: 8052597     PMC44409
16 Siuzdak G., Krebs J.F., Benkovic S.J., Dyson H.J.
Binding of Hapten to a Single-Chain Catalytic Antibody Demonstrated by Electrospray Mass Spectrometry
Journal of the American Chemical Society, 1994 116 7937-7938      PDF File                
15 Crano J., Knowles D., Kwiatkowski P., Flood T., Ross R., Chiang L., Lasch J., Chadha R., Siuzdak G.
Structure of Three Novel Photochromic Compounds; X-ray Crystallographic and Theoretical Studies
Acta Crystallographica Section B-Structure Science, 1994 50 772-779      PDF File                
14 Rideout D., Bustamante A., Siuzdak G.
Cationic drug analysis using matrix-assisted laser desorption/ionization mass spectrometry: application to influx kinetics, multidrug resistance, and intracellular chemical change
Proceedings of the National Academy of Sciences of the United States of America, 1993 90(21) 10226-10229      PDF File           PMID:8234281     PMC47747
13 Siuzdak G., Ichikawa Y., Munoz B., Caulfield T.J., Wong C.H., Nicolaou K.C.
Evidence of Calcium-Dependent Carbohydrate Association through Ion Spray Mass Spectrometry
Journal of the American Chemical Society, 1993 115 2877-2881      PDF File                
12 Siuzdak G., Wendeborn S.V., Nicolaou K.C.
Cationization of Organometallo Carbonyl Compounds by Fast Ion Bombardment
Intern. J. of Mass Spectrom. and Ion Proc., 1992 112 79-91      PDF File                
11 BelBruno J.J., Siuzdak G.
Resonant Ionization in Solution: Initiation of ion-molecule chemistry by REMPI
Resonance Ionization Spectroscopy 90, Inst. Phys. Conf. Ser., 1991 114 351-354      PDF File                
10 BelBruno J.J., Siuzdak G.
REMPI-MS: Application to the Study of the Gas Phase Dynamics of Radical Cations
Resonance Ionization Spectroscopy 90, Inst. Phys. Conf. Ser., 1991 114 177-180      PDF File                
9 Siuzdak G., BelBruno J.J.
Multiphoton Ionization of Nitrobenzene in Non-Aqueous Solutions: Characterization of the Cation and Ion-Molecule Chemistry
Laser Chemistry, 1991 11(2) 83-93      PDF File                
8 Siuzdak G., North S., BelBruno J.J.
Multiphoton Ionization of Phenol in NonAqueous Solutions: Characterization of the Cation and Ion-Molecule Chemistry
J. Phys. Chem., 1991 95(13) 5186-5190      PDF File                
7 BelBruno J.J., Siuzdak G., North S.
Multiphoton-Induced Chemistry of Phenol in Hexane at 266nm
Chem. Phys. Lett., 1990 166 167-172      PDF File                
6 BelBruno J.J., Siuzdak G., North S.
UV Multiphoton Induced Chemistry of Nitrobenzene in Solution
Laser Chemistry, 1990 10 177-184      PDF File                
5 Siuzdak G., BelBruno J.J.
Multiphoton Ionization Studies of Amines with UV-VIS Lasers
Applied Physics B, 1990 50 221-226      PDF File                
4 Siuzdak G., BelBruno J.J.
Laser Multiphoton Dissociation/Ionization of Butylamines: Competitive Processes in Radical Cations
J. Phys. Chem., 1990 94(11) 4559-4565      PDF File                
3 Siuzdak G.
Multiphoton-Induced Chemistry
Ph. D. Thesis University Microfilms International, Dissertation Abstracts International B, 1990 51(5)2385 166                      
2 Marzzacco C.J., Deckey G., Colarulli R., Siuzdak G., Halpern A.
Excited-State Protonation and Photophysical Properties of Azaphenanthrenes
J. Phys. Chem., 1989 93 2935-2939      PDF File                
1 Siuzdak G.
The protonation of 7,8-benzoquinoline in its lowest excited singlet
B.S. Thesis, Rhode Island College,, 1985