Our Research
There is an ever increasing range of applications involving Metabolomics and Mass Spectrometry. Highlighted below are publications directly related to some of our technologies and the areas of our research. For the full range of recent publications, see Google Scholar.
XCMS / METLIN
Our cloud-based XCMS metabolomics and systems biology platform originated in 2004, allowing us to examine metabolism on a global scale. Also created in 2004, METLIN now includes over a million molecules ranging from lipids, steroids, small peptides, exogenous drugs/metabolites, central carbon metabolites and toxicants. All molecules have either experimentally generated MS/MS data or in silico MS/MS data.
- Analytical Chemistry 2006 XCMS
- Therapeutic Drug Monitoring 2005 METLIN
- Analytical Chemistry 2008 Similarity Searching
- Analytical Chemistry 2012 XCMS Online
- Nature Biotechnology 2012 XCMS / METLIN
- Nature Protocols 2012 metaXCMS
- Nature Protocols 2013 LC MS/MS guided by METLIN
- Nature Biotechnology 2014 Data Streaming
- Analytical Chemistry 2016 Smartphone Analytics
- Trends in Biotech. 2017 Metabolizing Data in the Cloud
- Nature Methods 2017 Systems Biology & Metabolomics
- Nature Methods 2020 METLIN MS2 Molecular Standards Database
Activity Metabolomics
The driving force in our technology developments is applying them to unique problems including the microbiome, oncology, stem cell differentiation, pain, virology, imaging and more. In essence these studies have helped created the platform that is now used worldwide by over 16,000 researchers.
- Science 1995 Metabolism and Sleep
- PNAS 2009 Blood Microbiome
- Nature Chemical Biology 2010 Stem Cell Differentiation
- Nature Chemical Biology 2012 Chronic Pain
- Cell Metabolism 2015 Microbiome and Cancer
- Nat. Chem. Biol. 2017 Metabolic Modulation of Phenotype
- Science Signaling 2019 Metabolic Rewiring of the Kidney
- Science Signaling 2020 Metabolic Adaptation to Calorie Restriction
Nanostructure Imaging MS (NIMS)
Originally developed in 1999, our NIMS technology continues to evolve as we discover new ways to employ nanostructure materials to enhance imaging mass spectrometry.
Viruses and Microbes
Our original work with viruses and microbes delved into whole virus analysis, viral and microbial structure dynamics, and more recently the metabolism of viruses and microbes.
- Chemistry & Biology 1996 Intact Viral Analysis
- Nature Structural Biology 1999 Viral Capsid Dynamics
- PNAS 2001 Cold Virus Dynamics
- Nature 2005 Ribosome
- JCI 2008 Simian HIV
- PNAS 2009 Gut Microflora on Mammalian Blood Metabolites
- Nature 2010 Microbial Metalloproteome
- Cell Metabolism 2015 Metabolism Links Cancer & Biofilms
- Nature Communications 2019 Fiber-deprived Diet