Mass Spectrometry Services

We offer a wide range of analysis on several types of mass spectrometers, such as MALDI TOF, ESI quads, ESI TOF, ESI QTOF and ESI ion traps. We can handle a variety of different compounds including small molecules, peptides, proteins and oligonucleotides. Our proteomics service includes in-gel or in-solution proteolytic digestion, nano-LC-MS/MS or MALDI-TOF MS, and the identification of proteins based on database searching, plus characterizing post-translational modifications if desired. We also offer GC/MS and have expert staff on hand to handle custom mass spectrometry and method development.

If you are comfortable working with a mass spectrometer, we have several instruments in our Open Access Lab available to all. It takes only a brief training session to get started. If you are ready to submit samples please sign up at CoreService.

Pharmacokinetics

A Scripps Research multi-core effort can provide a complete PK analysis service from drug administration to quantitative analysis.

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Proteomics

We can identify proteins and post translational modifications using a procedure that includes digestion, nano-LC/MS/MS analysis and NCBI database searching.

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Open Access Lab

Reserve time on one of our Single Quadrupole, ESI-TOF, or MALDI-TOF mass spectrometers.

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Metabolomic Pathway Analysis

We offer Krebs Cycle (TCA) or Amino Acid analysis via HILIC chromatography using a triple quadrupole mass spectrometer with multiple reaction monitoring mode.

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MALDI-TOF

Our MALDI-TOF service can provide up to unit mass results on a variety of compounds including polymers and small oligonucleotides.

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Intact Protein Analysis

Proteins are analyzed via MALDI-TOF and ESI-TOF to provide m/z data. If you require protein characterization info on digested proteins we also offer Proteomics services.

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ESI-TOF

We can provide High accuracy m/z measurements with mass errors of less than 5ppm in either positive or negative modes.

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GC/MS

Our analysis is qualitative, giving chromatogram traces, ms spectra for all major peaks, and a library search. Best for compounds that easily vaporize and are kept in volatile solvents. Quantitative analysis is also available.

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Sample Shipping

The Scripps Research Institute
Center for Metabolomics and Mass Spectrometry
Mail Code: SR-28
9365 Waples St., Suite E
San Diego, CA 92121
United States

Note: Cold packages should arrive no later than Friday morning.

Sample Drop-Off

External customers please email us at masspec@scripps.edu or call 858-784-9415 between 10am and 4pm PST and make arrangements to meet outside the Beckman Building for Chemical Sciences.

Scripps employees can bring samples directly to The Stein Clinical Research Building, upper basement.

See also: Campus Map

Prices

All are per sample unless otherwise noted.
Service Description Internal NPO Regular
ESI High Accuracy High accuracy m/z measurements with mass errors of less than 5ppm for small molecules typically < 2,000 Da; 3,000 Da limit $15 $60 $100
ESI Unit Mass Unit mass results in positive or negative mode, typically 100 - 3,000 Da (Scripps users please submit to High Accuracy) $15 $50 $50
MALDI Unit mass results on a variety of compounds including peptides, carbohydrates, polymers and small oligonucleotides 1,000 - 200,000 Da, For small molecules please contact us first. $25 $50 $50
Intact Protein Analysis MALDI and ESI for Intact Proteins, Minimum 25μL of sample, Mass between 5,000 - 200,000 Da $75 $100 $150
GC/MS Small Hydrophopic Molecules < 500 Da $30 $60 $90
Proteomics ID Single Protein or Mixtures of Proteins Identified using LC/MS/MS $250 $325 $500
Proteomics PTM Protein PTMs Identified using LC/MS/MS $350 $350 $700
Metabolic Pathway Analysis Two types of analysis available, Krebs Cycle (TCA) or Amino Acid analysis. Please contact us to go over the details of your project. $70 $140 $140
LC/MS We offer case by case custom work. Please contact a scientist at our facility to help achieve your goals. Additional charges may apply. $75 $100 $150
Quantitative Analysis (LC/QQQ, RP-LC-QTOF and HILIC-LC-QTOF) We offer case by case custom work in which you will be in close contact with a scientist at our facility to help achieve your goals including specially tailored mass spec methods where needed. Method development charges may apply. $50 $100 $150
Open Access Single Quad With a brief training session you can gather your own mass spec data using one of our ESI-TOF or single quad instruments. $42/hr $95/hr $95/hr
Open Access TOF We offer a self-service High-Accuracy ESI-TOF and MALDI-TOF MSD for your samples. $60/hr $120/hr $120/hr
Open Access RAPID-MS We offer set rapid analysis methods with quick (2min) run-times for simple samples at a significantly reduced rate. $5/run NA NA