A Scripps Research multi-core effort can provide a complete PK analysis service from drug administration to quantitative analysis.
We can identify proteins and post translational modifications using a procedure that includes digestion, nano-LC/MS/MS analysis and NCBI database searching.
Open Access Lab
Reserve time on one of our Single Quadrupole, ESI-TOF, or MALDI-TOF mass spectrometers.
Metabolomic Pathway Analysis
We offer Krebs Cycle (TCA) or Amino Acid analysis via HILIC chromatography using a triple quadrupole mass spectrometer with multiple reaction monitoring mode.
Our MALDI-TOF service can provide up to unit mass results on a variety of compounds including polymers and small oligonucleotides.
Intact Protein Analysis
Proteins are analyzed via MALDI-TOF and ESI-TOF to provide m/z data. If you require protein characterization info on digested proteins we also offer Proteomics services.
We can provide High accuracy m/z measurements with mass errors of less than 5ppm in either positive or negative modes.
Our analysis is qualitative, giving chromatogram traces, ms spectra for all major peaks, and a library search. Best for compounds that easily vaporize and are kept in volatile solvents. Quantitative analysis is also available.
The Scripps Research Institute
Center for Metabolomics and Mass Spectrometry
Mail Code: SR-28
9365 Waples St., Suite E
San Diego, CA 92121
Note: Cold packages should arrive no later than Friday morning.
Scripps employees can bring samples directly to The Stein Clinical Research Building, upper basement.
See also: Campus Map
|ESI High Accuracy||High accuracy m/z measurements with mass errors of less than 5ppm for small molecules typically < 2,000 Da; 3,000 Da limit||$15||$60||$100|
|ESI Unit Mass||Unit mass results in positive or negative mode, typically 100 - 3,000 Da (Scripps users please submit to High Accuracy)||$15||$50||$50|
|MALDI||Unit mass results on a variety of compounds including peptides, carbohydrates, polymers and small oligonucleotides 1,000 - 200,000 Da, For small molecules please contact us first.||$25||$50||$50|
|Intact Protein Analysis||MALDI and ESI for Intact Proteins, Minimum 25μL of sample, Mass between 5,000 - 200,000 Da||$75||$100||$150|
|GC/MS||Small Hydrophobic Molecules < 500 Da||$30||$60||$90|
|Proteomics ID||Single Protein or Mixtures of Proteins Identified using LC/MS/MS||$250||$325||$500|
|Proteomics PTM||Protein PTMs Identified using LC/MS/MS||$350||$350||$700|
|Metabolic Pathway Analysis||Two types of analysis available, Krebs Cycle (TCA) or Amino Acid analysis. Please contact us to go over the details of your project.||$75||$100||$150|
|LC/MS||We offer case by case custom work. Please contact a scientist at our facility to help achieve your goals. Additional charges may apply.||$75||$100||$150|
|Quantitative Analysis||(LC/QQQ, RP-LC-QTOF and HILIC-LC-QTOF) We offer case by case custom work in which you will be in close contact with a scientist at our facility to help achieve your goals including specially tailored mass spec methods where needed. Method development charges may apply.||$75||$100||$150|
|Open Access Single Quad||With a brief training session you can gather your own mass spec data using one of our ESI-TOF or single quad instruments. (Minimum reservation charge of 30 minutes)||$42/hr||$95/hr||$95/hr|
|Open Access TOF||We offer a self-service High-Accuracy ESI-TOF and MALDI-TOF MSD for your samples. (Minimum reservation charge of 30 minutes)||$60/hr||$120/hr||$120/hr|
|Open Access RAPID-MS||We offer set rapid analysis methods with quick (2min) run-times for simple samples at a significantly reduced rate.||$5/run||NA||NA|